A Critical Analysis of the Role of Serotonin in Suicide.

A serotonergic dysfunction in the brain has been reported to be involved in suicidal behaviour independently of the attitude of a specific psychiatric disorder (Mann et al., 1999). The seretonergic sense organ mud is comprised of fourteen receptor subtypes that are subdivided into seven families (Raymond et al., 2001). The majority of studies pertain cerebrateed on serotonin receptor subtypes, and provoke suggested that any(prenominal) of the receptors whitethorn be especially involved in the pathogenesis of depression, suicidal behaviour, aggression and impulsivity. The for the first time part of this essay depart focus on the usance of serotonin, 5-hydroxytryptamine monoamine neurotransmission (5-HT) in self-annihilation. More specifically, it will look on the studies of the cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) which is the wizard metabolite of 5-HT in depression. The piece part of the essay will check the serotonin receptor abno rmalities. It will look at post-mortem receptor-binding studies that indicated abnormalities in the ventral prefrontal cortex of patients who committed suicide. Neurochemical abnormalities The 5-HT has a signalize role in the behaviour of humans and other species, much(prenominal) as impulsivity and aggression.

This is due to the 5-HT systems characteristics; they are the signal mediator for the effects of serotonin which is a healthy functional distributor of biliousness sensitivity. Many studies of suicide attempters have confirmed abnormalities in 5-HT neurotransmission and the gamble of sui cide has been strongly jibe with the belit! tled concentration of this neurotransmitter. This may be caused by dearths in the uptake of serotonin (Stoff & Mann, 1997). Alterations in neurotransmitter and neuromodulato receptor density could look an important role in the neurobiological basis of suicide (Bland, 1997). One of the possible causes of low concentration of CSF 5-HIAA can be explained by a deficit in platelet markers (Asberg & Forslund, 2000). However, the link...If you neediness to get a estimable essay, order it on our website: OrderCustomPaper.com

If you want to get a full essay, visit our page: write my paper